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Thursday, April 30, 2020 | History

5 edition of Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer found in the catalog.

Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer

Hong Yin

Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer

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  • 9 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Diseases - Cancer,
  • Health & Fitness,
  • Health/Fitness

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations, 834
    The Physical Object
    FormatPaperback
    ID Numbers
    Open LibraryOL12854056M
    ISBN 109155444377
    ISBN 109789155444372


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Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer by Hong Yin Download PDF EPUB FB2

Mouse mammary tumor virus (MMTV) was first linked to human breast cancer 50 years ago. 1 Today, however, the hypothesis that MMTV is etiologically linked to human breast cancer holds little traction with virologists or clinicians, for reasons that will be summarized later.

Nevertheless, a few groups have persevered with study of the MMTV Cited by: Mouse mammary tumor virus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and belongs to the genus was formerly known as Bittner virus, and previously the "milk factor", referring to the extra-chromosomal vertical transmission of murine breast cancer by adoptive nursing, demonstrated inby John Joseph Bittner while working at the Family: Retroviridae.

There is substantial evidence that a virus homologous to mouse mammary tumor virus (MMTV) may have a role in human breast Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer book.

The present study indicates that those who developed breast cancer associated with an MMTV-like virus had this virus in their non-cancerous breast tissues years before the Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer book developed.

Polymerase chain reaction (PCR) techniques and sequencing Cited by: Human mammary tumor virus (HMTV), a human homologue to the mouse mammary Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer book virus (MMTV) has been proposed by Pogo et al.

to play a role in IBC   Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in several studies from different geographical areas.

However, the role played by this virus in breast cancer tumorigenesis is not completely by: 4. Retroviral sequences % homologous to the mouse mammary tumor virus (MMTV) were Human Mouse Mammary Tumor Virus-Like Elements and Their Relation to Breast Cancer book in 38% of the breast cancers studied from American women and were not detectable in non-tumor breast tissue from the same patient.

The entire proviral structure was described and viral particles were isolated from primary cultures of human breast by:   Mouse mammary tumor virus (MMTV) is a well-known cause of mammary tumors in mice transmitted as endogenous proviruses or exogenously as infectious virions.

The hypothesis that a retrovirus homologous to MMTV is involved in human breast cancers has resulted in renewed interest in the etiology of human breast cancer. Therefore, the detection of MMTV-like exogenous sequences in Cited by: Mouse mammary tumor virus-like env gene sequences in human breast tumors and in a lymphoma of a breast cancer patient.

Clin Cancer Res. ; – Ford CE, Tran D, Deng Y, Ta VT, Rawlinson WD, Lawson JS. Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese by: Mouse mammary tumor virus (MMTV) has been proven to induce mammary cancer in mice.

MMTV-like env gene sequences have been detected in one-third of the human breast tumors studied. The whole proviral structure with 95% homology to MMTV was found in two human breast tumors and was designated as human mammary tumor virus (HMTV).Cited by:   Human mammary tumor virus (HMTV) is a breast cancer pathogen Breast cancer risk appears to be derived from a combination of factors, including genetic susceptibility, exposure to carcinogens, diet and other lifestyle factors, and harmful mutations that accumulate with age.

Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0–78%; however, the prevalence of HMTV in breast cancers from Myanmar remains by: 2.

We previously reported a bp mouse mammary tumor virus (MMTV)-like env gene sequence in approximately 38% of human breast cancer DNA, but not in normal breasts or other tumors.

This MMTV-like env gene sequence was expressed in 66% of the env gene-positive human breast cancers. An entire proviral structure was identified in human breast cancer DNA with high homology to Cited by: Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia Reem Al Dossary1*, Khaled R.

Alkharsah2 and Haitham Kussaibi3 Abstract Background: Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality.

The three viruses most studied as possible causes of human breast cancer are mouse mammary tumor virus-like sequences (MMTV-LS), Epstein-Barr virus (EBV), and oncogenic (high risk) types of human.

The role of mouse mammary tumor virus (MMTV) as a causative agent in human breast carcinogenesis has recently been the subject of renewed interest. The proposed model is based on the detection of MMTV sequences in human breast cancer but not in healthy breast tissue.

One of the main drawbacks to this model, however, was that until now human cells had not been demonstrated to Cited by: The breast is a paired globular body placed on the anterior parts of the chest side; its base extending from the second to the sixth rib.

Its main function is to produce milk to feed the newborn (Drew et al., ).Each breast contains a mammary gland, which is composed of 15–20 lobes and the fabric of support, which contains blood vessels, fibers, and fat ().Author: Marwah Labyed, Najwa Hassou, Bahia Bennani, Moulay Mustapha Ennaji.

The present invention relates to materials and methods for diagnosing breast cancer in humans. It is based, at least in part, on the discovery that a substantial percentage of human breast cancer tissue samples contained nucleic acid sequences corresponding to a portion of the mouse mammary tumor virus env gene.

While the best studied viral role in breast cancer are mouse mammary tumor virus-like sequences (MMTV-LS), Epstein-Barr virus (EBV) and human papillomavirus (HPV) recent recommendations highlighted the need for further studies to strengthen the preliminary data relating viral agents and breast cancer.

In this study, the authors determined if. Finally, other investigators have focused on MMTV, a B‐type retrovirus that is the major etiologic agent of breast cancer in mice.

50, 51 As reported by Etkind et al., 52 DNA sequences with homology to the MMTV ENV gene have been found in nearly 40% of human breast tumors, but less than 2% of normal breast tissue.

Two things argue against an. The Breast Cancer Surveillance Consortium (BCSC) is a research resource for studies designed to assess the delivery and quality of breast cancer screening and related patient outcomes in the United States.

The BCSC is a collaborative network of seven mammography registries with linkages to tumor and/or pathology registries. Full text of "Report of program activities: National Cancer Institute" See other formats. Investigators are searching for homologs of mouse mammary tumor virus (MMTV) or interactions with endogenous retroviruses in human breast cancer (Chapter 27).

One model posits that breast cancer is an MMTV zoonosis acquired from domestic mice (7). Breast cancer accounted for % of cases, 15% were diagnosed with lung cancer, % with colon cancer, and the remaining % suffered from genital/urinary cancer, gastrointestinal cancer.

Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen.

Immunol. – PubMed Google ScholarCited by: 3. Overview of Human Cancer Induction and Human Exposure to Carcinogens David Warshawsky and Joseph R.

Landolph, Jr. Complex Mixtures of Chemical Carcinogens: Principles of Action and Human Cancer Stephen Nesnow Lung Cancer Jay W. Tichelaar and George D. Leikauf Breast Cancer Sue C. Heffelfinger Cancer of the Prostate — Mechanisms of Molecular. Mouse Mammary Tumor Virus-like ENV Gene Sequences in Human Breast Tumors and in a Lymphoma of a Breast Cancer Patient Link; Section The HIV antibody test unlike all others has to be diluted.

This is because we are all positive and we are all positive –because the HIV antibody test just picks up any old retrovirus. And we are full of them. The problems of multiple pathogens and ingrained predispositions are now coming to a head in research on breast cancer.

Presently, three viruses have been associated with breast cancer: mouse mammary tumor virus, Epstein Barr virus, and human papillomavirus.

Researchers are still arguing about whether these correlations reflect causation. Other members of the Retroviridae family, such as Mouse mammary tumour virus (MMTV) have a well-defined link with tumours in mice, which are likely mediated by insertional activation of cellular genes in breast tissue through hormone responsive elements in the MMTV promoter.

[15] Similarly, insertional mutagenesis and the induction of lymphoma. Virus-Induced Tumors of Animals Virus-Induced Tumors of Animals Shrigley, E W While the concept is not new, appreciation of the fact that viruses or virus-like agents may possess the ability to elicit growths in animal tissues is entering the thinking of an ever-widening circle of modern oncologists.

The importance of these observations and the diversity of literature on. Similar to their mouse counterparts, the etiological roles of HERVs have been implicated in various types of human cancers or tumor cell lines.

The detection viral particles in a malignant melanoma cell culture [ 43, 44 ] and the overexpression of viral proteins encoded by HERV-K in germ cell tumors in several studies may reflect the Cited by: 4.

Using acid-fast staining techniques, bacteria have been identified in breast cancer, lymphoma, Kaposi’s sarcoma (the so-called “gay cancer” of AIDS) and other forms of cancer Figure 1 shows bacteria identified in breast cancer, indicating that such microbes are already present within the tumour and are not laboratory contaminants.

However, p53 can block the effect of caffeine on G2 arrest. For example, a breast cancer cell line with wildtype p53 arrests in G2 in response to DNA damage, and this effect could not be overcome by caffeine ().

However, when p53 was inactivated by expressing the E6 protein of the human papilloma virus, caffeine could abrogate the G2 arrest /5. The team combined tumor biology, metagenomics, metabolomics and modeling approaches to study the impact of the gut microbiome on colon cancer.

They demonstrated distinct roles for microbes and their metabolites in colon cancer mismatch repair status. For example, highly influential microbes included many butyrate producers. volume 28 Number 4 april EdiTORiAl What health reform means for innovation nEWS light micrograph of cultured human breast cancer cells.

weinberg and colleagues show that targeting a pro-metastatic microrNa with antagomirs prevents the formation of new metastases in a mouse model of breast cancer (p ). A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot.

Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Cancer is a complex disease, as has been amply shown by the mass of recently generated 'omics' data. Can the new US National Cancer Institute Physical Sciences-Oncology Centers initiative help us Cited by: KEYWORDS: Photodynamic therapy, Tumors, Tissues, Image segmentation, Collagen, Pancreas, Pancreatic cancer Read Abstract + While most cancer therapy options rely on a systemic delivery of pharmacologic drugs into the tumor site, physiologic barriers.

P30CA - Core Support for Cancer Research Center, P.H. Wiernik, Associate Director for Clinical Research, $1, direct year 15 for clinical core program.

National Cancer Institute. 06/01/82 - 10/06/ NO1-CM - Clinical Trials of Activated Human Leukocytes, P.H. Wiernik, principal investigator, $, direct year This paper dealt with the exposure of human lung, breast and uterine cancer tissue to ozone at concentrations of to parts per million, well within the non-toxic limits (OSHA standards).

More than 1, parts per million can be tolerated safely during the average ten minute period that medically administered ozone takes and. Clin Breast Cancer 5, Pasleau F, Grooteclaes, M and Gol-Winkler R () Expression of the c-erbB2 gene in theBT human mammary tumor cell line: measurement of c-erbB2 mRNA half-life.

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Full text of "Report of program activities: National Cancer Institute".